Tryptophan-Nicotinic Acid Metabolism in Patients with Tumours of the Bladder and Kidney

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Effect of Dietary Tryptophan Imbalance upon the Metabolism of Tryptophan and Nicotinic Acid in Man*

Growth of animals receiving diets low in protein and nicotinic acid may be retarded by the addition of corn products (l-4), of certain amino acids (5-9), or of proteins deficient in tryptophan (8-11). This inhibition, which is obtained with diets relatively deficient in tryptophan, can be overcome by the administration of nicotinic acid or of tryptophan (l-11). It has been suggested that this d...

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Tryptophan and nicotinic acid studies in man.

Recent studies have shown that tryptophan is effective in preventing or curing nicotinic acid deficiency in the rat (l), chick (2), mouse (3), dog (4), pig (5), and rabbit (6). Increased urinary excretion of nicotinic acid or P;S’-methylnicotinamide (NI-Me) after ingestion of tryptophan has been demonstrated in the rat (7), cotton rat (8), horse (8), pig (5), dog (4), calf (9), and human (10, 1...

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The metabolism of high intakes of tryptophan, nicotinamide and nicotinic acid in the rat.

1. The metabolic fate of high dietary intakes of nicotinamide, nicotinic acid and tryptophan, and of acute doses of nicotinamide and nicotinic acid, has been studied in the rat. A new high-pressure liquid chromatography method for measurement of the principal urinary metabolites of niacin is described. 2. Administration to rats of a single oral dose of nicotinamide or nicotinic acid (up to 100 ...

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ژورنال

عنوان ژورنال: British Journal of Cancer

سال: 1964

ISSN: 0007-0920,1532-1827

DOI: 10.1038/bjc.1964.44